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Pharmaceutical manufacturing

The dental ulcer treatment of Gargling and containing Strong

Resume:here casually choose conscious 68 patients who have dental ulcer after malignant tumor chemotherapy to be divided 2 groups.the contrast group use borax compound solution to gargle,the inspected group take strong acidic electrolyzed water to gargle 6 times a day before sleeping and eating.the result:the effectiveness rate of inspected group is 100%,and the cure rate of that is 76.48%.the contrast’s is 52.4% and 8.82%.through the statistics x2=36.39,p〈0.01.the difference of result shows that the acidic electrolyzed water is superior to the borax compound solution in the treatment of dental ulcer.

The dental ulcer is usual complication for chemotherapeutic patients after 7-14 days.if no treatment,it can make patients painful to infect the respiratory and digestive system.for the better treatment method,we have satisfied result to contrastive research between acidic electrolyzed water and borax compound solution in 1998.

1.documentary and method

1.1clinic documentary

The ulcer area is under 1cm2 for conscious patient after chemotherapy.here are 68 cancer patients who have two ulcer places,including 16 leukemia patients,3 multiple myeloma,7 malignant lymphoma,29 lung cancer,6 liver cancer,3 bone cancer,2colon cancer and 2 kidney cancer.the medicine are mitomycin,navelbine,adriamycin,methotexate,cytosine arabinoside,etoposide and mitoxantrone. The patoents are divided 2 groups,each group has 34 cases.the inspected group(male20,female 14 age:19-66 ).the contrast groups(male 23,female 11,age 21-63)without any difference for age and sex in statistics.

1.2method

Two groups take antibiotic and vitamin to treat according to the result of bacterial culture,please gargle with leukewarm before eating and sleeping.the inspect group take electrolyzed water 50ml in 13 minutes 6times a day.as is same with contrast group.inspect the ulcer condition at 10 o’clock every day and listen the patient’s offer.

1.3the standard of treatment

Cure:ulcer disappear in 1 week without any hurt.

Better:ulcer partially disappear relieving hurt

Non:ulcer not disappear in 1 week even more severe.

2 result(table 1)

Table 1 the contrast between 2 treat methods

group cases cure better non
Inspect group 34 26 8 10
Contrast group 34 3 15 16
total 68 29 23 16
 

3.Discussion

The dental ulcer appear in the decreased immunity.the absolute value of neutrophil reach the lowest after 7-14 days for chemotherapeutic patients with further impairment of bone marrow hematopoietic function,and less eating and more microbial group generation leading to weak the self-clean function to cause stink and to hurt oral mucosa reaching to the dental ulcer.

The method of gargling and containing in mouth is easily accepted by patients,because the liquid continually circulate and shock in mouth to make microbe attaching on the oral mucosa and dent out of mouth.if with the mingle of tongue,it can relieve the stink.

borax compound solution as traditional gargling liquid includes borax and bicarbonate yellow which has weak antimicrobial effect for skin and mucosa,it could not easily penetrate into skin and slowly discharge after absorption and being toxin after repeatedly having.

Strong acidic electrolyzed water generated from electrolyzed water generator which electrolyzed running water with 0.05% salt has killing bacterial properties(PH value 2.7,ORP〉1100mv,ACC 20-30mg/l).according to the reports:it can kill staphylococcus aureus,pseudomonas aeruginosa and escherichia coli in 1 minute,and kill candida albicans in 5 minutes,and bacillus subtilis var.niger in 20 minutes,and kill salmonella and vibrio sp. In 30 seconds.the oral infection is due to G-bacilli,anaerobic and candida albicans.the electrolyzed water has rapid and broad-spectrum killing ability from clinic practice.

Strong acidic water has the ability to activate the superficial cells,and to accelerate the cure,and touch with body to relieve the electron to down the ORP,and to restore the neutral PH value.it has no irritation and no odor for skin.because it can generatethe slight anaesthesia to relieve the hurt,it can be used the treatment of bedsore,infection and dermatitis.

Moreover,the strong acidic water can be reduce the running water in touch with light,air and organism.it is better to reserve in non-metal and close-space.for 30 days.it is better to use it when generates.

4.Conclusion

Strong acidic water has properties:broad-spectrum of killing microbe,rapid function,non-pollution,low-cost,good effect,non-irritation,non-odor.the editor suggest is can takes place of borax compound solution in the time of dental ulcer.

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